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A helicase-tethered ORC flip enables bidirectional helicase loading
In this study I use single-molecule microscopy and FRET to discover how eukaryotic DNA helicases are deposited at origins in a head-to-head orientation that ensures DNA replication is bidirectional.
Shalini Gupta, Larry J Friedman, Jeff Gelles, Stephen P Bell
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A helicase-tethered ORC flip enables bidirectional helicase loading
Mechanism and kinetics of aztreonam hydrolysis catalyzed by class-C β-lactamase: A temperature-accelerated sliced sampling study
Enhanced sampling of large number of collective variables (CVs) is inevitable in molecular dynamics (MD) simulations of complex …
Shalini Awasthi, Shalini Gupta, Ravi Tripathi, Nisanth N Nair
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