Shalini Gupta, PhD

Shalini Gupta, PhD

Postdoctoral Fellow, Genentech
San Francisco Bay Area

Hello and welcome to my website! I am a postdoctoral fellow at Genentech, before which I was a graduate student at MIT. I study the biochemistry of living systems, specifically large molecular machines that work in teams. I am interested in harnessing insight into molecular function to manipulate biology in cells, and for therapeutic discovery. I am also passionate about teaching, mentoring, and effective communication.

In my PhD research with Stephen P. Bell at MIT, I used single-molecule microscopy to discover how eukaryotic DNA helicases are deposited on DNA to ensure DNA replication is bidirectional. I discovered that a helicase-loader protein called the origin-recognition complex (ORC) performs a flip in order to recruit two copies of the eukaryotic DNA helicase in opposite orientations to one another. If this all sounds pretty unbelievable, check out our paper below to learn more!

Download my CV (2022).

Interests
  • Biochemistry and Biophysics
  • DNA replication
  • Chromatin remodelers
  • Biology education
Education
  • PhD in Biochemistry, 2022

    Massachusetts Institute of Technology

  • BS in Chemistry, 2016

    Indian Institute of Technology (IIT) Kanpur

All Publications

(2021). A helicase-tethered ORC flip enables bidirectional helicase loading. In eLife.

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